Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that recognize nuclear
macromolecules and their complexes. ANAs represent key biomarkers in the evaluation of …

The sleep disorder narcolepsy is linked to the HLA-DQB1* 0602 haplotype and
dysregulation of the hypocretin ligand-hypocretin receptor pathway. Narcolepsy was …

Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment
of multiple cancers. However, these promising therapies may also cause immune-related …

Connective tissue diseases (CTDs) such as systemic lupus erythematosus, systemic
sclerosis, myositis, Sjögren's syndrome, and rheumatoid arthritis are systemic diseases …

Autoreactive B and T cells are present in healthy, autoimmunity-free individuals, but they are
kept in check by various regulatory mechanisms. In systemic lupus erythematosus (SLE) …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a poorly
understood preclinical stage of immune dysregulation and symptom accrual. Accumulation …

The presence of antinuclear antibodies (ANA) is mainly associated with connective tissue
diseases (CTD). In addition, their presence is found in healthy people. These antibodies are …

There is growing evidence that preceding the diagnosis or classification of systemic lupus
erythematosus (SLE), patients undergo a preclinical phase of disease where markers of …

Established and emerging data demonstrate that a'preclinical'period of disease precedes
the onset of clinical rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as …