Multi-species analyses of direct activators of the constitutive androstane receptor
CJ Omiecinski, DM Coslo, T Chen… - Toxicological …, 2011 - academic.oup.com
The constitutive androstane receptor (CAR; NR1I3) is a member of the nuclear receptor
superfamily and functions as an important xenochemical sensor and transcriptional …
superfamily and functions as an important xenochemical sensor and transcriptional …
Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes
M Gährs, R Roos, PL Andersson, D Schrenk - Toxicology and applied …, 2013 - Elsevier
Polychlorinated biphenyls (PCBs) are among the most ubiquitously detectable 'persistent
organic pollutants'. In contrast to 'dioxinlike'(DL) PCBs, less is known about the molecular …
organic pollutants'. In contrast to 'dioxinlike'(DL) PCBs, less is known about the molecular …
In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets
The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor orchestrating
complex roles in cell and systems biology. Species differences in CAR's effector pathways …
complex roles in cell and systems biology. Species differences in CAR's effector pathways …
Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk
Introduction: Protein-protein interaction and signaling crosstalk contribute to the regulation of
pregnane X receptor (PXR) and constitutive androstane receptor (CAR) and broaden their …
pregnane X receptor (PXR) and constitutive androstane receptor (CAR) and broaden their …
An update on the constitutive androstane receptor (CAR)
F Molnár, J Küblbeck, J Jyrkkärinne… - Drug metabolism and …, 2013 - degruyter.com
The constitutive androstane receptor (CAR; NR1I3) has emerged as one of the main drug-
and xenobiotic-sensitive transcriptional regulators. It has a major effect on the expression of …
and xenobiotic-sensitive transcriptional regulators. It has a major effect on the expression of …
Phenobarbital meets phosphorylation of nuclear receptors
M Negishi - Drug Metabolism and Disposition, 2017 - ASPET
Phenobarbital was the first therapeutic drug to be characterized for its induction of hepatic
drug metabolism. Essentially at the same time, cytochrome P450, an enzyme that …
drug metabolism. Essentially at the same time, cytochrome P450, an enzyme that …
Phosphorylated nuclear receptor CAR forms a homodimer to repress its constitutive activity for ligand activation
The nuclear receptor CAR (NR1I3) regulates hepatic drug and energy metabolism as well
as cell fate. Its activation can be a critical factor in drug-induced toxicity and the development …
as cell fate. Its activation can be a critical factor in drug-induced toxicity and the development …
Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes
T Sueyoshi, L Li, H Wang, R Moore… - Toxicological …, 2014 - academic.oup.com
Abstract Polybrominated diphenyl ether BDE-47 (2, 2′, 4, 4′-tetrabromodiphenyl ether) is
a thyroid hormone disruptor in mice; hepatic induction of various metabolic enzymes and …
a thyroid hormone disruptor in mice; hepatic induction of various metabolic enzymes and …
Constitutive androstane receptor (CAR) is a xenosensor and target for therapy
EM Kachaylo, VO Pustylnyak, VV Lyakhovich… - Biochemistry …, 2011 - Springer
Constitutive androstane receptor (CAR, NR1I3), which is under consideration in this review,
is a member of the superfamily of nuclear receptors. However, certain features distinguish …
is a member of the superfamily of nuclear receptors. However, certain features distinguish …
Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors
Abstract The bacteriostat triclosan (2, 4, 4′-trichloro-2′-hydroxydiphenylether)(TCS)
decreases rat serum thyroxine via putative nuclear receptor (NR) interaction (s) and …
decreases rat serum thyroxine via putative nuclear receptor (NR) interaction (s) and …