Mechanism and medical implications of mammalian autophagy

I Dikic, Z Elazar - Nature reviews Molecular cell biology, 2018 - nature.com
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Autophagy and doxorubicin resistance in cancer

C Chen, L Lu, S Yan, H Yi, H Yao, D Wu, G He… - Anti-cancer …, 2018 - journals.lww.com
Doxorubicin (DOX), also known as adriamycin, is a DNA topoisomerase II inhibitor and
belongs to the family of anthracycline anticancer drugs. DOX is used for the treatment of a …

Resveratrol as a natural regulator of autophagy for prevention and treatment of cancer

Y Tian, W Song, D Li, L Cai, Y Zhao - OncoTargets and therapy, 2019 - Taylor & Francis
Resveratrol, as a natural product compound, has been recently attracted much attention for
its potent effects on cancer. Cancer is a serious disease threatening human survival and …

Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives

Y Chen, X Tan, W Zhang, Y Li, X Deng… - Phytotherapy …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer‐
related mortality, continues to pose significant challenges in the realm of medical oncology …

Exploring the role of autophagy dysfunction in neurodegenerative disorders

T Rana, T Behl, A Sehgal, V Mehta, S Singh… - Molecular …, 2021 - Springer
Autophagy is a catabolic pathway by which misfolded proteins or damaged organelles are
engulfed by autophagosomes and then transported to lysosomes for degradation. Recently …

[HTML][HTML] Recent progress in the role of autophagy in neurological diseases

T Meng, S Lin, H Zhuang, H Huang, Z He, Y Hu… - Cell Stress, 2019 - ncbi.nlm.nih.gov
Autophagy (here refers to macroautophagy) is a catabolic pathway by which large protein
aggregates and damaged organelles are first sequestered into a double-membraned …

Resveratrol suppresses melanoma by inhibiting NF-κB/miR-221 and inducing TFG expression

F Wu, L Cui - Archives of dermatological research, 2017 - Springer
Resveratrol (Res) is a natural compound with anti-cancer effects. The goal of this study is to
evaluate the suppression of Res in melanoma and investigate its relationship with miRNAs …

Plant-derived natural coumarins with anticancer potentials: Future and challenges

A Gangopadhyay - Journal of Herbal Medicine, 2023 - Elsevier
Introduction This review provides an extensive summary of the anticancer property of new
natural coumarins. These coumarins comprise simple coumarin, furanocoumarin …

Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies

Z Ji, J Shen, Y Lan, Q Yi, H Liu - MedComm, 2023 - Wiley Online Library
Osteosarcoma (OS) is a highly prevalent bone malignancy among adolescents, accounting
for 40% of all primary malignant bone tumors. Neoadjuvant chemotherapy combined with …

Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy

T Xu, Z Zheng, Y Guo, LP Bai - European Journal of Medicinal Chemistry, 2020 - Elsevier
Magnolol, a natural bioactive neolignan, was found in the bark of a traditional Chinese
medicine Magnoliae officinalis (“Hou Po” in Chinese). In this study, thrity-two magnolol …