Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary
escalator, intercellular apical junctional complexes which regulate paracellular permeability …

Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Cystic fibrosis (CF) lung disease involves chronic bacterial infection of retained airway
secretions (mucus). Recent data suggest that CF lung disease pathogenesis reflects the …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

Dysfunction of CFTR in cystic fibrosis (CF) airway epithelium perturbs the normal regulation
of ion transport, leading to a reduced volume of airway surface liquid (ASL), mucus …

Acetylcholine (ACh), a classical transmitter of parasympathetic nerve fibres in the airways, is
also synthesized by a large number of non-neuronal cells, including airway surface …

The human lung produces considerable amounts of H2O2. In the normal uninflamed
epithelium of both the airways and the alveoli, mucosal release of H2O2 is readily detected …

Submucosal glands (SMGs) protect lungs but can also contribute to disease. For example, in
cystic fibrosis (CF), SMGs produce abnormal mucus that disrupts mucociliary transport. CF is …

Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous
airways. Although it has been assumed that SMGs contribute to respiratory defense, that …