Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction
times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion …

The mobility of transposable elements (TEs) contributes to evolution of genomes. Their
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …

Bdelloid rotifers are part of the restricted circle of multicellular animals that can withstand a
wide range of genotoxic stresses at any stage of their life cycle. In this study, bdelloid rotifer …

Developing accurate and sensitive DNA methyltransferase (MTase) analysis methods is
essential for early clinical diagnosis and development of antimicrobial drug targets. In this …

Abstract N4-methylcytosine (4mC) is an important DNA chemical modification pattern which
is a new methylation modification discovered in recent years and plays critical roles in gene …

N 6-Methyladenine (6mdA) and N 4-methylcytosine (4mdC) are the two most dominant DNA
modifications in both prokaryotes and eukaryotes, but standard hybridization-based …

DNA modifications add another layer of complexity to the eukaryotic genome to regulate
gene expression, playing critical roles as epigenetic marks. In eukaryotes, the study of DNA …

Our understanding of the mechanisms that modulate gene expression in animals is strongly
biased by studying a handful of model species that mainly belong to three groups: Insecta …