Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …

Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is
a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains …

The TRP ion channel TRPM2 has an essential function in cell survival and protects the
viability of a number of cell types after oxidative stress. It is highly expressed in many …

The mechanism of pancreatic cancer (PA) is not fully understanded. In our last report,
TRPM2 plays a promising role in pancreatic cancer. However, the mechanism of TRPM2 is …

Background: Cisplatin is a widely used anti-tumor agent but its use is frequently limited by
nephrotoxicity. Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation …

Cisplatin resistance is one of the main causes of treatment failure and death in head and
neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the …

Numerous studies have reported a strong association between increased production of
reactive oxygen species (ROS) and the pathobiology of several diseases, and cancer in …

TRPM2 is a versatile and essential signaling molecule that plays diverse roles in Ca2+
homeostasis and oxidative stress signaling, with implications in various diseases. Research …

Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …