Activation of the lysosomal damage response and selective autophagy: the coordinated actions of galectins, TRIM proteins, and CGAS-STING1 in providing immunity …
Autophagy is a crucial immune defense mechanism that controls the survival and
pathogenesis of M. tb by maintaining cell physiology during stress and pathogen attack. The …
pathogenesis of M. tb by maintaining cell physiology during stress and pathogen attack. The …
Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins
TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil
domains. These proteins are efficient regulators of autophagy, apoptosis, and innate …
domains. These proteins are efficient regulators of autophagy, apoptosis, and innate …
TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux
D Zhao, L Qiang, Z Lei, P Ge, Z Lu, Y Wang, X Zhang… - Autophagy, 2024 - Taylor & Francis
Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB),
remain a global threat exacerbated by increasing drug resistance. Host-directed therapy …
remain a global threat exacerbated by increasing drug resistance. Host-directed therapy …
TRIMming down Mycobacterium tuberculosis replication: TRIM32 is required for bacterial ubiquitination and autophagy induction in macrophages
Mycobacterium tuberculosis (Mtb) promotes its intracellular persistence by subverting
defense mechanisms, such as autophagy. Remarkably, enhancing autophagy is sufficient to …
defense mechanisms, such as autophagy. Remarkably, enhancing autophagy is sufficient to …