[HTML][HTML] Inflammation: A key process in skin tumorigenesis

M Neagu, C Constantin, C Caruntu… - Oncology …, 2019 - spandidos-publications.com
The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major
scientific interest. While the inflammation induced by environmental agents has well known …

CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis

S Mii, A Enomoto, Y Shiraki, T Taki… - Pathology …, 2019 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol‐anchored glycoprotein and a member of the α2‐
macroglobulin/C3, C4, C5 family of thioester‐containing proteins first identified as being …

[HTML][HTML] Aptamer-based CRISPR/Cas12a assay for the ultrasensitive detection of extracellular vesicle proteins

H Li, S Xing, J Xu, Y He, Y Lai, Y Wang, G Zhang… - Talanta, 2021 - Elsevier
Tumor-derived extracellular vesicles (TEVs) have emerged as promising sources of
diagnostic and prognostic biomarkers for nasopharyngeal carcinoma (NPC). However, the …

Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin… - Cancer …, 2020 - Wiley Online Library
Lung cancer is the most commonly diagnosed cancer worldwide, and metastasis in lung
cancer is the leading cause of cancer‐related deaths. Thus, understanding the mechanism …

CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF‐β signaling

T Taki, Y Shiraki, A Enomoto, L Weng, C Chen… - Cancer …, 2020 - Wiley Online Library
Stromal invasion is considered an important prognostic factor in patients with lung
adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal …

CD 109 deficiency induces osteopenia with an osteoporosis‐like phenotype in vivo

S Mii, A Hoshino, A Enomoto, Y Murakumo… - Genes to …, 2018 - Wiley Online Library
Osteoporosis is a global public health problem that is increasing along with an aging
population. A major determinant of osteoporosis is high bone turnover, which results from …

[HTML][HTML] CD109 and squamous cell carcinoma

R Qi, F Dong, Q Liu, Y Murakumo, J Liu - Journal of Translational …, 2018 - Springer
Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor
prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein …

[HTML][HTML] Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase

H Inaba, D Yamakawa, Y Tomono, A Enomoto… - Biochemical and …, 2018 - Elsevier
We previously reported that vimentin, GFAP, and desmin (type III intermediate filament [IF]
proteins) are mitotically phosphorylated by CDK1, Aurora-B, and Rho-kinase. This …

Serum CD109 levels reflect the node metastasis status in head and neck squamous cell carcinoma

S Hagiwara, E Sasaki, Y Hasegawa, H Suzuki… - Cancer …, 2021 - Wiley Online Library
Background Various biomarkers are being developed for the early diagnosis of cancer and
for predicting its prognosis. The aim of this study is to evaluate the diagnostic significance of …

[HTML][HTML] Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute …

R Hornung, V Jurinovic, AMN Batcha… - Scientific Reports, 2018 - nature.com
Alterations of RUNX1 in acute myeloid leukemia (AML) are associated with either a more
favorable outcome in the case of the RUNX1/RUNX1T1 fusion or unfavorable prognosis in …