Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - Signal transduction and …, 2022 - nature.com
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …
Targeting hypoxic tumor microenvironment in pancreatic cancer
J Tao, G Yang, W Zhou, J Qiu, G Chen, W Luo… - Journal of hematology & …, 2021 - Springer
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
The enhancement of glycolysis regulates pancreatic cancer metastasis
J Yang, B Ren, G Yang, H Wang, G Chen, L You… - Cellular and Molecular …, 2020 - Springer
Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …
Role of HIF-1 in cancer progression: novel insights. A review
A Pezzuto, E Carico - Current molecular medicine, 2018 - ingentaconnect.com
Hypoxia is a condition always present in tumor environment owing to the fast growth of
tumor cells not supported by adequate blood supply. There is increasing evidence that …
tumor cells not supported by adequate blood supply. There is increasing evidence that …
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
M Akman, DC Belisario, IC Salaroglio… - Journal of Experimental …, 2021 - Springer
Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
condition, together with the aberrant activation of specific oncogenic patwhays, increases …
HIF-1 in cancer therapy: two decade long story of a transcription factor
Abstract Background: Oxygen (O2) homeostasis is an indispensable requirement of
eukaryotes. O2 concentration in cellular milieu is defined as normoxia (∼ 21% O2) …
eukaryotes. O2 concentration in cellular milieu is defined as normoxia (∼ 21% O2) …
[HTML][HTML] Drug resistance in pancreatic cancer: Impact of altered energy metabolism
C Grasso, G Jansen, E Giovannetti - Critical reviews in oncology …, 2017 - Elsevier
Pancreatic cancer is a highly deadly disease: almost all patients develop metastases and
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …
Redox balance and autophagy regulation in cancer progression and their therapeutic perspective
Cellular ROS production participates in various cellular functions but its accumulation
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …
The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …
several cell functions of cancer cells. Several natural products modulate both oxidative …
Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
X Jin, L Dai, Y Ma, J Wang, Z Liu - Cancer Cell International, 2020 - Springer
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …