Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus
aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum …

Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's
disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects …

The Candida genus comprises opportunistic fungi that can become pathogenic when the
immune system of the host fails. Candida albicans is the most important and prevalent …

The production of natural antibiotic peptides has emerged as an important mechanism of
innate immunity in plants and animals. Defensins are diverse members of a large family of …

Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological
role in vivo has been proposed to be the elimination of pathogenic microorganisms …

Defensins are small, multifunctional cationic peptides. They typically contain six conserved
cysteines whose three intramolecular disulfides stabilize a largely β‐sheet structure. This …

The growing public health problem of infections caused by multiresistant Gram-positive
bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for …

Plant defensins are small, basic peptides that have a characteristic three-dimensional
folding pattern that is stabilized by eight disulfide-linked cysteines. They are termed plant …

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …