Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …

The brain is a highly compartmentalized organ exceptionally susceptible to accumulation of
metabolic errors. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease …

Accumulation of cerebral amyloid-β peptide (Aβ) is essential for developing synaptic and
cognitive deficits in Alzheimer's disease. However, the physiological functions of Aβ, as well …

Formation of senile plaques containing the β-amyloid peptide (Aβ) derived from the amyloid
precursor protein (APP) is an invariant feature of Alzheimer's disease (AD). APP is cleaved …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for
degrading normal and aggregated proteins, particularly under stress or injury conditions …

The amyloid precursor protein (APP) plays a central role in the pathophysiology of
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …

Twenty-five years ago, little was known about the causes of neurodegenerative diseases.
Now, however, it is clear that they result from abnormalities in the processing of proteins. In …