CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology.
In the decades since its initial discovery, their biogenesis, regulation, and function have …

The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in
bone metabolism, mammary epithelial cell development, immune function, and cancer …

To devise a highly effective implant for addressing bone metastasis with the unique
capability of self-oxygen generation, a multifunctional film was engineered using a Layer-by …

This review delves into the intricate interplay between osteoporosis, its treatment
approaches, and oral health. The examination underscores the substantial impact of …

Repair of large bone defects remains to be clinically challenging, yet current bone repair
strategies focus on optimizing the osteogenic capacity of bone grafts, while the role of …

Cancer has a high morbidity (19 million new cases) and high mortality (7-10 million new
deaths) annually worldwide [1, 2]. Neoplasm metastasis is responsible for nearly 90% of …

Objective This study aimed to assess the results of primary stereotactic body radiotherapy
(SBRT) for spinal bone metastases (SBM) originating from lung adenocarcinoma (ADC). We …

Bulgarian real-world data on denosumab use for the prevention of skeletal-related events
(SREs) associated with bone metastases (BM) from prostate cancer (PC) are lacking. This …

Breast cancer (BC) is the leading cause of death among females worldwide. The disease is
classified into four molecular subtypes: luminal A, luminal B, overexpressed HER2, and …

As the global number of patients with osteoporosis and malignant diseases such as breast
cancer, multiple myeloma, and prostate cancer increases every year, there is an associated …