Consumer and environmental safety decisions are based on exposure and hazard data,
interpreted using risk assessment approaches. The adverse outcome pathway (AOP) …

The incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise
world-wide. The liver is a central insulin-responsive metabolic organ that governs whole …

Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of chronic liver
disease, representing the leading cause of hepatology referral in some centres. However, its …

Compared with our ancestors, Western societies today lead a lifestyle that is much more
sedentary, probably as a result of cultural changes stemming from modern socio-economic …

NF-E2-related factor 2 (Nrf2) is a transcription factor that is activated by oxidative stress and
electrophiles that regulates the expression of numerous detoxifying and antioxidant genes …

Epidemiological studies in humans, as well as experimental studies in animal models, have
shown an association between visceral obesity and dyslipidemia, insulin resistance, and …

Among commonly consumed anti-inflammatory and antimicrobial drugs are diclofenac
sodium (DFS) and oxytetracycline (OTC), especially in developing countries because they …

Obesity is commonly associated with nonalcoholic fatty liver (NAFL), a benign condition
characterized by hepatic lipid accumulation. However, NAFL can progress in some patients …

OBJECTIVES: Nonalcoholic steatohepatitis (NASH) is considered the hepatic manifestation
of metabolic syndrome (MetS) among adults. Emerging data suggest that MetS may be …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …