Development of testes in the mammalian embryo requires the formation and assembly of
several cell types that allow these organs to achieve their roles in male reproduction and …

The detrimental effects of Zika virus (ZIKV) infection on mouse testicular functions have
reminded a viral threat to male fertility. A broad range of virus families has tropism for male …

Germline development in vivo is dependent on the environment formed by somatic cells and
the differentiation cues they provide; hence, the impact of local factors is highly relevant to …

The testis must create and maintain an immune privileged environment to protect maturing
germ cells from autoimmune destruction. The establishment of this protective environment is …

Testicular germ cells, which appear after the establishment of central tolerance, express
novel cell surface and intracellular proteins that can be recognized as 'foreign antigens' by …

The purpose of this review is to describe the endocrine and local testicular factors that
contribute to the regulation of the blood-testis barrier (BTB), using information gained from in …

Immunoregulation in the testis is characterized by a balance between immuno-suppression
(or immune privilege) and the ability to react to infections and inflammation. In this review …

Glucocorticoids are steroid hormones that regulate diverse cellular functions and are
essential to facilitate normal physiology. However, stress-induced levels of glucocorticoids …

The male genital tract (MGT) is the target of a number of viral infections that can have
deleterious consequences at the individual, offspring, and population levels. These …

The immune privilege of the testes is necessary to prevent immune attacks to gamete-
specific antigens and paternal major histocompatibility complex (MHC) antigens, allowing …