Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

At sites of vascular injury, platelets come into contact with the subendothelial extracellular
matrix which triggers their activation and the formation of a hemostatic plug. This process is …

Platelet adhesion, activation and aggregation on the exposed subendothelial extracellular
matrix (ECM) are essential for haemostasis, but may also lead to occlusion of diseased …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Background—Blocking of glycoprotein VI–dependent pathways by interfering in vascular
collagen sites is commonly seen as an attractive target for an antiplatelet therapy of acute …

To date, 33 human platelet alloantigens (HPA s) have been identified on six functionally
important platelet glycoprotein (GP) complexes and have been implicated in alloimmune …

Platelet activation and subsequent thrombus formation at sites of vascular injury is crucial for
normal hemostasis, but it can also cause myocardial infarction and stroke. The initial capture …