[HTML][HTML] The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …
Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐κB Suppression and NLRP3 …
Y Ran, W Su, F Gao, Z Ding, S Yang… - Oxidative medicine …, 2021 - Wiley Online Library
NLRP3 inflammasome‐mediated pyroptosis is a proinflammatory programmed cell death
pathway, which plays a vital role in functional outcomes after stroke. We previously …
pathway, which plays a vital role in functional outcomes after stroke. We previously …
Curcumin: an inflammasome silencer
Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
[HTML][HTML] A novel combination of vitamin C, curcumin and glycyrrhizic acid potentially regulates immune and inflammatory response associated with coronavirus …
L Chen, C Hu, M Hood, X Zhang, L Zhang, J Kan, J Du - Nutrients, 2020 - mdpi.com
Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The
recurrent spreading of CoVs imposes an ongoing threat to global health and the economy …
recurrent spreading of CoVs imposes an ongoing threat to global health and the economy …
[HTML][HTML] Herbal drug discovery for the treatment of nonalcoholic fatty liver disease
Few medications are available for meeting the increasing disease burden of nonalcoholic
fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH) …
fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH) …
Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent
Monocytes and macrophages are important cells of the innate immune system that have
diverse functions, including defense against invading pathogens, removal of dead cells by …
diverse functions, including defense against invading pathogens, removal of dead cells by …
[HTML][HTML] Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol
S Habtemariam - Biomedicines, 2023 - mdpi.com
Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
[HTML][HTML] Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
B Chen, H Li, G Ou, L Ren, X Yang, M Zeng - Arthritis research & therapy, 2019 - Springer
Background Gouty arthritis is characterized by the deposition of monosodium urate (MSU)
within synovial joints and tissues due to increased urate concentrations. In this study, we …
within synovial joints and tissues due to increased urate concentrations. In this study, we …
Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases
X Zhang, A Xu, J Lv, Q Zhang, Y Ran, C Wei… - European journal of …, 2020 - Elsevier
NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is
activated by pathogen and damage-associated signals to form a multimeric protein complex …
activated by pathogen and damage-associated signals to form a multimeric protein complex …