Oxidative damage to RNA is altered by the presence of interacting proteins or modified nucleosides

M Estevez, S Valesyan, M Jora, PA Limbach… - Frontiers in Molecular …, 2021 - frontiersin.org
Oxidative stress triggered by the Fenton reaction (chemical) or UVR exposure (photo) can
damage cellular biomolecules including RNA through oxidation of nucleotides. Besides …

Andrographolide sodium bisulfate attenuates UV‑induced photo‑damage by activating the keap1/Nrf2 pathway and downregulating the NF‑κB pathway in HaCaT …

ML Wang, QY Zhong, BQ Lin… - International …, 2020 - spandidos-publications.com
Oxidative and inflammatory damage has been suggested to play important roles in the
pathogenesis of skin photoaging. Andrographolide sodium bisulfate (ASB) is a soluble …

Experimental evolution of UV resistance in a phage

EF Tom, IJ Molineux, ML Paff, JJ Bull - PeerJ, 2018 - peerj.com
The dsDNA bacteriophage T7 was subjected to 30 cycles of lethal ultraviolet light (UV)
exposure to select increased resistance to UV. The exposure effected a 0.9999 kill of the …

A single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes

HP Valerio, FG Ravagnani, GE Ronsein… - Scientific Reports, 2021 - nature.com
Epidermal photoaging contributes to skin fragility over time and it is a risk factor for skin
cancer. Photoaging has been associated for a long time with exposure to Ultraviolet-A (UVA) …

Transcription blockage by DNA damage in nucleotide excision repair-related neurological dysfunctions

GS Kajitani, LL de Souza Nascimento… - Seminars in Cell & …, 2021 - Elsevier
Human genetic syndromes deficient in nucleotide excision repair (NER), such as xeroderma
pigmentosum and Cockayne syndrome, may present neurological abnormalities and …

Recent advances in exosomal non‐coding RNA‐based therapeutic approaches for photoaging

KJ Li, PJ Zhou, YN Guo, TX Xu, SF Lin… - Skin Research and …, 2023 - Wiley Online Library
Background Photoaging is a degenerative biological process that affects the quality of life. It
is caused by environmental factors including ultraviolet radiation (UVR), deep skin burns …

DNA damage and deficiencies in the mechanisms of its repair: implications in the pathogenesis of systemic lupus erythematosus

MP Mireles-Canales… - Journal of …, 2018 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the
pathogenesis of which is yet to be understood. SLE is considered to be a multifactorial …

Antioxidants in Photoaging: From Molecular Insights to Clinical Applications

MJ Calvo, C Navarro, P Durán… - International Journal of …, 2024 - mdpi.com
Photoaging (PA) is considered a silent disease affecting millions of people globally and is
defined as skin damage due to prolonged exposure to ultraviolet radiation (UVR) from the …

Preserved riparian forest protects endangered forest-specialists amphibian species against the genotoxic impact of sunlight and agrochemicals

MC da Rocha, MB dos Santos, R Zanella… - Biological …, 2020 - Elsevier
Although agrochemicals and solar ultraviolet (UV) radiation are both environmental
stressors currently associated with amphibian decline, little is known about their interactive …

[HTML][HTML] Ultraviolet B irradiation induces senescence of human corneal endothelial cells in vitro by DNA damage response and oxidative stress

GJ Jiang, XG You, TJ Fan - Journal of Photochemistry and Photobiology B …, 2022 - Elsevier
The human corneal endothelial cells (HCEnCs) play a vital role in the maintenance of
corneal transparency and visual acuity. In our daily life, HCEnCs are inevitably exposed to …