Astrocytes in human central nervous system diseases: a frontier for new therapies
A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …
and defence of the central nervous system (CNS). Astroglia contribute to the …
Physiology of astroglia
A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
Glia as architects of central nervous system formation and function
Glia constitute roughly half of the cells of the central nervous system (CNS) but were long-
considered to be static bystanders to its formation and function. Here we provide an …
considered to be static bystanders to its formation and function. Here we provide an …
Molecular mechanisms of brain water transport
N MacAulay - Nature Reviews Neuroscience, 2021 - nature.com
Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …
compartments and cell types during physiological and pathophysiological processes …
The structure and function of the Na, K-ATPase isoforms in health and disease
MV Clausen, F Hilbers, H Poulsen - Frontiers in physiology, 2017 - frontiersin.org
The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …
for numerous processes, and the range of demands requires that the responsible ion pump …
Molecular pathophysiology of cerebral edema
JA Stokum, V Gerzanich… - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
Advancements in molecular biology have led to a greater understanding of the individual
proteins responsible for generating cerebral edema. In large part, the study of cerebral …
proteins responsible for generating cerebral edema. In large part, the study of cerebral …
Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
Molecular mechanisms of epilepsy
K Staley - Nature neuroscience, 2015 - nature.com
Decades of experimental work have established an imbalance of excitation and inhibition as
the leading mechanism of the transition from normal brain function to seizure. In epilepsy …
the leading mechanism of the transition from normal brain function to seizure. In epilepsy …
Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis
QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
Astrogliosis: an integral player in the pathogenesis of Alzheimer's disease
LM Osborn, W Kamphuis, WJ Wadman, EM Hol - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle
decline in episodic memory followed by a more general decline in overall cognitive abilities …
decline in episodic memory followed by a more general decline in overall cognitive abilities …