Long noncoding RNA MIAT modulates the extracellular matrix deposition in leiomyomas by sponging MiR-29 family

TD Chuang, D Quintanilla, D Boos, O Khorram - Endocrinology, 2021 - academic.oup.com
The objective of this study was to determine the expression and functional role of a long
noncoding RNA (lncRNA) MIAT (myocardial infarction–associated transcript) in leiomyoma …

Further characterization of tryptophan metabolism and its dysregulation in fibroids

TD Chuang, D Quintanilla, D Boos, O Khorram - F&S Science, 2022 - Elsevier
Objective To determine the expression of enzymes in tryptophan (Trp) catabolism in fibroids
and matched myometrium and determine the effects of race and mediator complex subunit …

The effect of race/ethnicity and MED12 mutation on the expression of long non-coding RNAs in uterine leiomyoma and myometrium

TD Chuang, N Ton, S Rysling, D Boos… - International journal of …, 2024 - mdpi.com
The objective of this study was to elucidate the expression of long non-coding RNA
(lncRNA) in leiomyomas (Lyo) and paired myometrium (Myo) and explore the impact of race …

Gene variants polymorphisms and uterine leiomyoma: an updated review

S Upadhyay, PK Dubey - Frontiers in Genetics, 2024 - frontiersin.org
Uterine leiomyoma, commonly referred to as fibroids, is a benign tumor that develops in the
muscular wall of the uterus. These growths are non-cancerous and can vary in size, ranging …

[HTML][HTML] Vilaprisan in women with uterine fibroids: the randomized phase 2b ASTEROID 1 study

LD Bradley, SS Singh, J Simon… - Fertility and sterility, 2019 - Elsevier
Objectives To assess the safety and efficacy of four vilaprisan doses (0.5–4.0 mg) in women
with uterine fibroids. Design Randomized, double-blind, placebo-controlled, multicenter trial …

Isoliquiritigenin suppresses E2-induced uterine leiomyoma growth through the modulation of cell death program and the repression of ECM accumulation

PH Lin, HL Kung, HY Chen, KC Huang, SM Hsia - Cancers, 2019 - mdpi.com
Uterine leiomyomas, also known as fibroids, are common and prevalent in women of
reproductive age. In this study, the effect of Isoliquiritigenin (ISL), a licorice flavonoid, on the …

Therapeutic effects of in vivo administration of an inhibitor of tryptophan 2, 3-dioxygenase (680c91) for the treatment of fibroids: a preclinical study

TD Chuang, N Ton, S Rysling, D Quintanilla, D Boos… - Fertility and sterility, 2024 - Elsevier
Objective Fibroids are characterized by marked overexpression of tryptophan 2, 3
dioxygenase (TDO2). The objective of this study was to determine the effectiveness of in vivo …

Biological and mechanistic characterization of novel prodrugs of green tea polyphenol epigallocatechin gallate analogs in human leiomyoma cell lines

RSI Ahmed, G Liu, A Renzetti, P Farshi… - Journal of Cellular …, 2016 - Wiley Online Library
Uterine fibroids (leiomyomas) are very common benign tumors grown on the smooth muscle
layer of the uterus, present in up to 75% of reproductive‐age women and causing significant …

[PDF][PDF] Современные представления об этиопатогенезе и факторах риска лейомиомы матки

ИВПономаренко, МИЧурносов Современные представления об этиопатог Page 1 1 ИВПономаренко,
МИЧурносов Современные представления об этиопатогенезе и факторах риска лейомиомы …

Myomas: anatomy and related issues.

A Tinelli, R Sparic, S Kadija, I Babovic… - Minerva …, 2016 - europepmc.org
Myomas are the most common disorder of the female genital organs, occurring more
frequently throughout women's reproductive years. Myomas are a major health issue all over …