Recently discovered interstitial cells “telocytes” as players in the pathogenesis of uterine leiomyomas

I Varga, M Klein, L Urban, L Danihel Jr, S Polak… - Medical hypotheses, 2018 - Elsevier
Uterine telocytes are interstitial cells characterized by a very long cytoplasmic prolongations,
which form a 3D network, functionally integrating a wide variety of different cells …

Expression levels of myostatin and matrix metalloproteinase 14 mRNAs in uterine leiomyoma are correlated with dysmenorrhea

A Tsigkou, FM Reis, P Ciarmela, MH Lee… - Reproductive …, 2015 - journals.sagepub.com
Uterine leiomyoma is the most common benign neoplasm of female reproductive system,
found in about 50% of women in reproductive age. The mechanisms of leiomyoma growth …

[HTML][HTML] Cross-talk between miR-29c and transforming growth factor-β3 is mediated by an epigenetic mechanism in leiomyoma

TD Chuang, O Khorram - Fertility and sterility, 2019 - Elsevier
Objective To determine the expression of miR-29c and its target gene transforming growth
factor-β3 (TGF-β3) in leiomyoma and the mechanisms of their reciprocal regulation. Design …

MiR-150-5p May Contribute to Pathogenesis of Human Leiomyoma via Regulation of the Akt/p27Kip1 Pathway In Vitro

JH Lee, YS Choi, JH Park, H Kim, I Lee… - International Journal of …, 2019 - mdpi.com
Uterine leiomyoma is found in~ 50–80% of women of a reproductive age and is the most
common reason for hysterectomy. Recently, posttranscriptional gene silencing by …

“Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid …

L Yu, J Liu, Y Yan, A Burwell, L Castro, M Shi… - Archives of …, 2021 - Springer
Cadmium (Cd) is a toxic metal reported to act as an estrogen “mimic” in the rat uterus and in
vitro. We have reported that Cd stimulates proliferation of estrogen-responsive human …

Comparison of uterine scarring between robot-assisted laparoscopic myomectomy and conventional laparoscopic myomectomy

BC Sheu, KJ Huang, SC Huang… - Journal of Obstetrics and …, 2020 - Taylor & Francis
This study compared uterine wound healing after robot-assisted laparoscopic myomectomy
(RM) and laparoscopic myomectomy (LM). Ultrasound was used to evaluate the scar repair …

[HTML][HTML] Factors affecting the loss of MED12-mutated leiomyoma cells during in vitro growth

J Bloch, C Holzmann, D Koczan, BM Helmke… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Uterine leiomyomas (UL) are the most prevalent symptomatic human tumors at all and
somatic mutations of the gene encoding mediator subcomplex 12 (MED12) constitute the …

The Rising Phoenix‐Progesterone as the Main Target of the Medical Therapy for Leiomyoma

HH Chill, M Safrai, A Reuveni Salzman… - BioMed research …, 2017 - Wiley Online Library
Leiomyomas, also known as uterine fibroids, are a common benign tumor in women of
reproductive age. These lesions disrupt the function of the uterus causing menorrhagia and …

Differential expression of super-enhancer-associated long non-coding RNAs in uterine leiomyomas

TD Chuang, D Quintanilla, D Boos, O Khorram - Reproductive Sciences, 2022 - Springer
Super-enhancer-associated long non-coding RNAs (SE-lncRNAs) are a specific set of
lncRNAs transcribed from super-enhancer (SE) genomic regions. Recent studies have …

Targeted adenoviral vector demonstrates enhanced efficacy for in vivo gene therapy of uterine leiomyoma

M Abdelaziz, L Sherif, M ElKhiary, S Nair… - Reproductive …, 2016 - journals.sagepub.com
Background: Gene therapy is a potentially effective non-surgical approach for the treatment
of uterine leiomyoma. We demonstrated that targeted adenovirus vector, Ad-SSTR-RGD …