Targeting α‐synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease
Lewy bodies that contain aggregated α‐synuclein in dopamine neurons are the main culprit
for neurodegeneration in Parkinson's disease. However, mitochondrial dysfunction has a …
for neurodegeneration in Parkinson's disease. However, mitochondrial dysfunction has a …
[HTML][HTML] Lipids uniquely alter secondary structure and toxicity of lysozyme aggregates
Abrupt aggregation of misfolded proteins is a hallmark of the large group of amyloid
pathologies that include diabetes type 2, Alzheimer and Parkinson's diseases. Protein …
pathologies that include diabetes type 2, Alzheimer and Parkinson's diseases. Protein …
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission
Mitochondria form tubular networks that undergo coordinated cycles of fission and fusion.
Emerging evidence suggests that a direct yet unresolved interaction of the …
Emerging evidence suggests that a direct yet unresolved interaction of the …
The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine
Progressive degeneration of dopaminergic neurons in the midbrain, hypothalamus, and
thalamus is a hallmark of Parkinson's disease (PD). Neuronal death is linked to the abrupt …
thalamus is a hallmark of Parkinson's disease (PD). Neuronal death is linked to the abrupt …
Role of saturation and length of fatty acids of phosphatidylserine in the aggregation of transthyretin
The progressive accumulation of transthyretin (TTR), a small protein that transports
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
Unravelling the structural organization of individual α-synuclein oligomers grown in the presence of phospholipids
Parkinson's disease (PD) is a severe neurological disorder that affects more than 1 million
people in the US alone. A hallmark of PD is the formation of intracellular α-synuclein (α-Syn) …
people in the US alone. A hallmark of PD is the formation of intracellular α-synuclein (α-Syn) …
Electroneutral Polymer Nanodiscs Enable Interference‐Free Probing of Membrane Proteins in a Lipid‐Bilayer Environment
D Glueck, A Grethen, M Das, OP Mmeka, EP Patallo… - Small, 2022 - Wiley Online Library
Membrane proteins can be examined in near‐native lipid‐bilayer environments with the
advent of polymer‐encapsulated nanodiscs. These nanodiscs self‐assemble directly from …
advent of polymer‐encapsulated nanodiscs. These nanodiscs self‐assemble directly from …
Multiplicity of α-synuclein aggregated species and their possible roles in disease
P Gracia, JD Camino, L Volpicelli-Daley… - International journal of …, 2020 - mdpi.com
α-Synuclein amyloid aggregation is a defining molecular feature of Parkinson's disease,
Lewy body dementia, and multiple system atrophy, but can also be found in other …
Lewy body dementia, and multiple system atrophy, but can also be found in other …
Elucidation of Secondary Structure and Toxicity of α-Synuclein Oligomers and Fibrils Grown in the Presence of Phosphatidylcholine and Phosphatidylserine
T Dou, M Matveyenka, D Kurouski - ACS Chemical Neuroscience, 2023 - ACS Publications
Abrupt aggregation of α-synuclein (α-Syn) in the midbrain hypothalamus and thalamus is a
hallmark of Parkinson's disease (PD), the fastest growing neurodegenerative pathology …
hallmark of Parkinson's disease (PD), the fastest growing neurodegenerative pathology …
Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders
Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy
bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as …
bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as …