Lipid membranes have recently been implicated in protein misfolding and disease etiology,
including for α-synuclein and Parkinson's disease. However, studying the intersection of …

Human amyloids and plaques uncovered post mortem are highly heterogeneous in structure
and composition, yet literature concerning the heteroaggregation of amyloid proteins is …

Synucleins are a family of small, soluble proteins mainly expressed in neural tissue and in
certain tumors. Since their discovery, tens of thousands of scientific reports have been …

Protein regions which are intrinsically disordered, exist as an ensemble of rapidly
interconverting structures. Cooling proteins to cryogenic temperatures for dynamic nuclear …

Abrupt aggregation of α-synuclein (α-Syn) leads to a formation of highly toxic protein
oligomers. These aggregates are the underlying molecular cause of an onset of the …

Alpha-synuclein (αS) is an extensively studied protein due to its involvement in a group of
neurodegenerative disorders, including Parkinson′ s disease, and its documented ability to …

α-Synuclein (αS) is a presynaptic protein that binds to cell membranes and is linked to
Parkinson's disease (PD). Binding of αS to membranes is a likely first step in the molecular …

Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and
modulate the physical state of membranes across species. Through these interactions …

The presence of amyloid fibrils is a hallmark of several neurodegenerative diseases. Some
amyloidogenic proteins, such as α-synuclein and amyloid β, interact with lipids, and this …

Abstract α-Synuclein (αS) deposition is a defining characteristic of Parkinson's disease (PD)
pathology, and other synucleinopathies. αS aggregates in disease, leading to the …