Lewy pathology in Parkinson's disease consists of a crowded organellar, membranous medley
Parkinson's disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …
[HTML][HTML] Multisite interactions of prions with membranes and native nanodiscs
Although prions are known as protein-only infectious particles, they exhibit lipid specificities,
cofactor dependencies and membrane-dependent activities. Such membrane interactions …
cofactor dependencies and membrane-dependent activities. Such membrane interactions …
How epigallocatechin gallate binds and assembles oligomeric forms of human alpha-synuclein
The intrinsically disordered human protein α-synuclein (αSN) can self-associate into
oligomers and amyloid fibrils. Several lines of evidence suggest that oligomeric αSN is …
oligomers and amyloid fibrils. Several lines of evidence suggest that oligomeric αSN is …
Large Unilamellar Vesicles of Phosphatidic Acid Reduce the Toxicity of α-Synuclein Fibrils
Parkinson's disease (PD) is a severe pathology that is caused by a progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta as well as other …
degeneration of dopaminergic neurons in substantia nigra pars compacta as well as other …
Conformational Selection of α-Synuclein Tetramers at Biological Interfaces
Controlling the polymorphic assemblies of α-synuclein (αS) oligomers is crucial to reroute
toxic protein aggregation implicated in Parkinson's disease (PD). One potential mediator is …
toxic protein aggregation implicated in Parkinson's disease (PD). One potential mediator is …
Folding of N-terminally acetylated α-synuclein upon interaction with lipid membranes
Abstract α-Synuclein (α-syn) is an abundant presynaptic neuronal protein whose
aggregation is strongly associated with Parkinson's disease. It has been proposed that lipid …
aggregation is strongly associated with Parkinson's disease. It has been proposed that lipid …
Molecular dynamics study of the interaction between the N-terminal of α-synuclein and a lipid bilayer mimicking synaptic vesicles
The interaction between α-synuclein (α-syn) and synaptic vesicles (SVs) plays an important
role in the life cycle of α-syn, and a disruption of it could lead to numerous …
role in the life cycle of α-syn, and a disruption of it could lead to numerous …
A charged tail on anti-α-Synuclein antibodies does not enhance their affinity to α-Synuclein fibrils
I Petersen, A Godec, F Ranjbarian, A Hofer… - Plos one, 2024 - journals.plos.org
The aggregation of α-Synuclein (αSyn) is strongly linked to neuronal death in Parkinson's
disease and other synucleinopathies. The spreading of aggregated αSyn between neurons …
disease and other synucleinopathies. The spreading of aggregated αSyn between neurons …
[HTML][HTML] Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration
F Yeboah, TE Kim, A Bill, U Dettmer - Neurobiology of disease, 2019 - Elsevier
Abstract α-Synuclein (αS) and tau have a lot in common. Dyshomeostasis and aggregation
of both proteins are central in the pathogenesis of neurodegenerative diseases: Parkinson's …
of both proteins are central in the pathogenesis of neurodegenerative diseases: Parkinson's …
[HTML][HTML] Elucidating the mechanisms of α-Synuclein-lipid interactions using site-directed mutagenesis
Abstract α-Synuclein (α-syn) is a small protein that is involved in cell vesicle trafficking in
neuronal synapses. A progressive aggregation of this protein is the expected molecular …
neuronal synapses. A progressive aggregation of this protein is the expected molecular …