Protein folding in vivo has been largely understood in the context of molecular chaperones
preventing aggregation of nascent polypeptides in the crowded cellular environment …

Different genetic backgrounds can modify the effect of mutated genes. Human α-synuclein
(SNCA) gene encodes α-synuclein, and its oligomeric complexes accumulate with age and …

Protein/lipid coassembly is an understudied phenomenon that is important to the function of
antimicrobial peptides as well as the pathological effects of amyloid. Here, we study the …

Elucidating the conformational preferences of regions of intrinsic disorder in biologically
relevant contexts represents a frontier of structural biology. The sensitivity enhancements …

Abstract Petersen, I. 2024. Targeting pathological alpha-synuclein. Protein engineering
towards improved antibody-based therapeutics and their delivery to the brain. Digital …

Abstract α-Synuclein (α-Syn), is an intrinsically disordered protein present in the substantia
nigra part of the brain. α-Syn is commonly known to associate with lipid membranes …

Parkinson's disease (PD) is the second-most common neurodegenerative disorder among
seniors after Alzheimer's disease, affecting 2-3% of the population over 65 years old. While …

Abstract The human Aquaporin-1 (AQP1) membrane protein is integral towards many
cellular processes involved with water permeability. This thesis explores two separate …

Alpha-Synuclein (αS) is a small intrinsically disordered protein (IDP) abundantly expressed
in presynaptic terminals of neurons that displays a highly amyloidogenic nature …

Morbus Alzheimer ist die häufigste altersbedingte neurodegenerative Krankheit und die
häufigste Ursache für eine Demenzerkrankung. Die Alzheimer-Krankheit ist bisher nicht …