Habitualmente se denomina agregación amiloide a aquel proceso de malplegamiento
proteico que comprende la transición de una proteína soluble y funcional a especies …

Structural biology is targeting increasingly complex systems. Emerging fields such as
cellular structural biology consequently apply integrative approaches that combine the …

Molecular dynamics simulations solve Newton's equations of motion for a system of
interacting atoms using the energy gradient calculated from a potential function which …

How do membrane proteins get into shape? How do they fold in their natural environment to
function without errors? The aim of this work was to find answers to these questions by using …

A large number of cellular processes is regulated by a complex interplay between several
hormones, membrane-embedded proteins and lipids. Especially G protein-coupled …

Neurodegenerative diseases (NDs) are a diverse group of diseases involving the
progressive damage or death of neuronal cells. Different parts of the brain or central nervous …

The transition of amyloidogenic species into ordered structures (ie, prefibrillar oligomers,
protofibrils, mature fibrils, and amyloidogenic aggregates) is closely associated with many …

Along with an increasing life expectancy in the population comes more incidences of
ageassociated disorders like Parkinson's disease (PD), affecting 1% of the population over …

Signaling of the Epidermal growth factor receptors (EGFRs) is a central cellular element and
its dysregulation is related to a number of severe diseases. While ligand binding to the …

The cell membrane, made up of a complex arrangement of proteins and lipids, is an integral
component of cells and functions as a protective barrier around cells. Interactions with cell …