Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Developmental origins of health and disease (DOHaD) is the study of how the early life
environment can impact the risk of chronic diseases from childhood to adulthood and the …

Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …

Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …

The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …