Translational perspective on epigenetics in cardiovascular disease
A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …
expression and providing a basis for the development and progression of cardiovascular …
Mediation by placental DNA methylation of the association of prenatal maternal smoking and birth weight
Prenatal maternal smoking is a risk factor for lower birth weight. We performed epigenome-
wide association analyses of placental DNA methylation (DNAm) at 720,077 cytosine …
wide association analyses of placental DNA methylation (DNAm) at 720,077 cytosine …
Body mass index drives changes in DNA methylation: a longitudinal study
Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
[HTML][HTML] Epigenetic contribution to obesity
M Ouni, A Schürmann - Mammalian genome, 2020 - Springer
Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated
via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) …
via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) …
[HTML][HTML] DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
Background DNA methylation has been shown to be associated with adiposity in adulthood.
However, whether similar DNA methylation patterns are associated with childhood and …
However, whether similar DNA methylation patterns are associated with childhood and …
[HTML][HTML] Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI
This study sought to examine the association between DNA methylation and body mass
index (BMI) and the potential of BMI-associated cytosine-phosphate-guanine (CpG) sites to …
index (BMI) and the potential of BMI-associated cytosine-phosphate-guanine (CpG) sites to …
DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework
Multiple differentially methylated sites and regions associated with adiposity have now been
identified in large-scale cross-sectional studies. We tested for replication of associations …
identified in large-scale cross-sectional studies. We tested for replication of associations …
[HTML][HTML] DNA-methylation and body composition in preschool children: epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-Study
P Rzehak, M Covic, R Saffery, E Reischl, S Wahl… - Scientific reports, 2017 - nature.com
Adiposity and obesity result from the interaction of genetic variation and environmental
factors from very early in life, possibly mediated by epigenetic processes. Few Epigenome …
factors from very early in life, possibly mediated by epigenetic processes. Few Epigenome …
[HTML][HTML] A negative feedback loop between TET2 and leptin in adipocyte regulates body weight
Q Zeng, J Song, X Sun, D Wang, X Liao, Y Ding… - Nature …, 2024 - nature.com
Abstract Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to
regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine …
regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine …
DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood
SJ Van Dijk, TJ Peters, M Buckley, J Zhou… - International journal of …, 2018 - nature.com
Results: No individual methylation sites at birth were associated with obesity or insulin
sensitivity measures at 5 years. DNA methylation in 69 genomic regions at birth was …
sensitivity measures at 5 years. DNA methylation in 69 genomic regions at birth was …