[HTML][HTML] Modular engineering for microbial production of carotenoids

C Li, CA Swofford, AJ Sinskey - Metabolic Engineering Communications, 2020 - Elsevier
There is an increasing demand for carotenoids due to their applications in the food, flavor,
pharmaceutical and feed industries, however, the extraction and synthesis of these …

Highly efficient neutralizer-free l-malic acid production using engineered Saccharomyces cerevisiae

L Sun, Q Zhang, X Kong, Y Liu, J Li, G Du, X Lv… - Bioresource …, 2023 - Elsevier
In industrial bioproduction of organic acids, numerous neutralizers are required which
substantially increases production costs and burdens the environment. To address this …

Engineering monoterpene production in yeast using a synthetic dominant negative geranyl diphosphate synthase

C Ignea, M Pontini, ME Maffei, AM Makris… - ACS synthetic …, 2014 - ACS Publications
Monoterpenes have an established use in the food and cosmetic industries and have
recently also found application as advanced biofuels. Although metabolic engineering …

Chemicals from lignocellulosic biomass: a critical comparison between biochemical, microwave and thermochemical conversion methods

IKM Yu, H Chen, F Abeln, H Auta, J Fan… - Critical Reviews in …, 2021 - Taylor & Francis
The past decades have seen an increasing interest in developing pathways to produce bio-
based chemicals from lignocellulosic biomass and organic waste as renewable resources …

In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli

F Zhu, X Zhong, M Hu, L Lu, Z Deng… - Biotechnology and …, 2014 - Wiley Online Library
Approaches using metabolic engineering and synthetic biology to overproduce terpenoids,
such as the precursors of taxol and artemisinin, in microbial systems have achieved initial …

Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes—current status and future opportunities

BM Lange, A Ahkami - Plant biotechnology journal, 2013 - Wiley Online Library
Terpenoids (aka isoprenoids) represent the most diverse class of natural products found in
plants, with tens of thousands of reported structures. Plant‐derived terpenoids have a …

What makes a P450 tick?

AW Munro, HM Girvan, AE Mason, AJ Dunford… - Trends in biochemical …, 2013 - cell.com
The cytochromes P450 (P450s) are probably nature's most versatile enzymes in terms of
both their vast substrate range and the diverse types of molecular transformations performed …

[HTML][HTML] Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

GR Navale, MS Dharne, SS Shinde - Applied Microbiology and …, 2021 - Springer
Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

Compartmentalization and transporter engineering strategies for terpenoid synthesis

K Jin, H Xia, Y Liu, J Li, G Du, X Lv, L Liu - Microbial Cell Factories, 2022 - Springer
Microbial cell factories for terpenoid synthesis form a less expensive and more environment-
friendly approach than chemical synthesis and extraction, and are thus being regarded as …

Cell-Free Mixing of Escherichia coli Crude Extracts to Prototype and Rationally Engineer High-Titer Mevalonate Synthesis

QM Dudley, KC Anderson, MC Jewett - ACS synthetic biology, 2016 - ACS Publications
Cell-free metabolic engineering (CFME) is advancing a powerful paradigm for accelerating
the design and synthesis of biosynthetic pathways. However, as most cell-free biomolecule …