Engineering plant sesquiterpene synthesis into yeasts: a review

J Mai, W Li, R Ledesma-Amaro… - Journal of Agricultural and …, 2021 - ACS Publications
Sesquiterpenes are natural compounds composed of three isoprene units. They represent
the largest class of terpene compounds found in plants, and many have remarkable …

[HTML][HTML] Fermentative production of Vitamin E tocotrienols in Saccharomyces cerevisiae under cold-shock-triggered temperature control

B Shen, P Zhou, X Jiao, Z Yao, L Ye, H Yu - Nature communications, 2020 - nature.com
The diverse physiological functions of tocotrienols have listed them as valuable
supplementations to α-tocopherol-dominated Vitamin E products. To make tocotrienols more …

[HTML][HTML] Microbial utilization of next-generation feedstocks for the biomanufacturing of value-added chemicals and food ingredients

C Zhang, C Ottenheim, M Weingarten… - … in Bioengineering and …, 2022 - frontiersin.org
Global shift to sustainability has driven the exploration of alternative feedstocks beyond
sugars for biomanufacturing. Recently, C1 (CO2, CO, methane, formate and methanol) and …

Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes—current status and future opportunities

BM Lange, A Ahkami - Plant biotechnology journal, 2013 - Wiley Online Library
Terpenoids (aka isoprenoids) represent the most diverse class of natural products found in
plants, with tens of thousands of reported structures. Plant‐derived terpenoids have a …

Artemisinin, a miracle of traditional Chinese medicine

LY Kong, RX Tan - Natural Product Reports, 2015 - pubs.rsc.org
The 2015 Nobel Prize in Physiology or Medicine, shared by Professor Youyou Tu, focused
worldwide attention on artemisinin, a natural product antimalarial drug inspired by traditional …

Cell-Free Mixing of Escherichia coli Crude Extracts to Prototype and Rationally Engineer High-Titer Mevalonate Synthesis

QM Dudley, KC Anderson, MC Jewett - ACS synthetic biology, 2016 - ACS Publications
Cell-free metabolic engineering (CFME) is advancing a powerful paradigm for accelerating
the design and synthesis of biosynthetic pathways. However, as most cell-free biomolecule …

[HTML][HTML] Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate

C Ignea, MH Raadam, MS Motawia, AM Makris… - Nature …, 2019 - nature.com
Synthetic biology efforts for the production of valuable chemicals are frequently hindered by
the structure and regulation of the native metabolic pathways of the chassis. This is …

Biodefense in the age of synthetic biology

National Academies of Sciences, Division on Earth… - 2018 - books.google.com
Scientific advances over the past several decades have accelerated the ability to engineer
existing organisms and to potentially create novel ones not found in nature. Synthetic …

[HTML][HTML] Producing aglycons of ginsenosides in bakers' yeast

Z Dai, B Wang, Y Liu, M Shi, D Wang, X Zhang, T Liu… - Scientific reports, 2014 - nature.com
Ginsenosides are the primary bioactive components of ginseng, which is a popular
medicinal plant that exhibits diverse pharmacological activities. Protopanaxadiol …

Synthesis of customized petroleum-replica fuel molecules by targeted modification of free fatty acid pools in Escherichia coli

TP Howard, S Middelhaufe, K Moore… - Proceedings of the …, 2013 - National Acad Sciences
Biofuels are the most immediate, practical solution for mitigating dependence on fossil
hydrocarbons, but current biofuels (alcohols and biodiesels) require significant downstream …