[HTML][HTML] Targeting hypoxic tumor microenvironment in pancreatic cancer
J Tao, G Yang, W Zhou, J Qiu, G Chen, W Luo… - Journal of hematology & …, 2021 - Springer
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
[HTML][HTML] Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal Transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
The role of hypoxia‐inducible factor 1 in tumor immune evasion
L You, W Wu, X Wang, L Fang, V Adam… - Medicinal research …, 2021 - Wiley Online Library
Abstract Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor
microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression …
microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression …
[HTML][HTML] CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p
Y Xi, Y Shen, D Wu, J Zhang, C Lin, L Wang, C Yu… - Molecular cancer, 2022 - Springer
Abstract Rationale Circular RNAs (circRNAs) have been demonstrated to contribute to
esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be …
esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be …
[HTML][HTML] The role of cancer-derived microRNAs in cancer immune escape
M Yi, L Xu, Y Jiao, S Luo, A Li, K Wu - Journal of hematology & oncology, 2020 - Springer
During malignant transformation, accumulated somatic mutations endow cancer cells with
increased invasiveness and immunogenicity. Under selective pressure, these highly …
increased invasiveness and immunogenicity. Under selective pressure, these highly …
[HTML][HTML] circRNA-miRNA-mRNA regulatory network in human lung cancer: an update
ZZ Liang, C Guo, MM Zou, P Meng, TT Zhang - Cancer cell international, 2020 - Springer
Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been
studied, probed and applied into several diseases, such as cardiovascular diseases …
studied, probed and applied into several diseases, such as cardiovascular diseases …
[HTML][HTML] Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10
R Yang, H Chen, L Xing, B Wang, M Hu, X Ou, H Chen… - Molecular cancer, 2022 - Springer
Background Hypoxia has long been considered as a hallmark of solid tumors and is closely
associated with tumor progression. Circular RNAs (circRNAs) have been identified as a …
associated with tumor progression. Circular RNAs (circRNAs) have been identified as a …
[HTML][HTML] Roles of circRNAs in the tumour microenvironment
Q Zhang, W Wang, Q Zhou, C Chen, W Yuan, J Liu… - Molecular cancer, 2020 - Springer
The tumour microenvironment (TME) constitutes the area surrounding the tumour during its
development and has been demonstrated to play roles in cancer-related diseases through …
development and has been demonstrated to play roles in cancer-related diseases through …
[HTML][HTML] Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
X Jin, L Dai, Y Ma, J Wang, Z Liu - Cancer Cell International, 2020 - Springer
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …
[HTML][HTML] Metabolic reprogramming of immune cells in pancreatic cancer progression
H Xiang, R Yang, J Tu, Y Xi, S Yang, L Lv, X Zhai… - Biomedicine & …, 2023 - Elsevier
Abnormal intracellular metabolism not only provides nutrition for tumor occurrence and
development, but also sensitizes the function of various immune cells in the immune …
development, but also sensitizes the function of various immune cells in the immune …