Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Dietary intake of caffeine has significantly increased in recent years, and beneficial and
harmful effects of caffeine have been extensively studied. This paper reviews antioxidant …

Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Decades of research have demonstrated an incontrovertible role of amyloid-β (Aβ) in the
etiology of Alzheimer's disease (AD). However, the overemphasis on the pathological …

Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease
(PD) are characterized by the impairment of memory and motor functions, respectively …

Multiple sevoflurane exposures may damage the developing brain. The neuroprotective
function of dexmedetomidine has been widely confirmed in animal experiments and human …

Germinal matrix-intraventricular hemorrhage (GM-IVH) is the most frequent intracranial
hemorrhage in the preterm infant (PT). Long-term GM-IVH-associated sequelae include …

Aims: Caffeine possesses potent antioxidant, anti-inflammatory and anti-apoptotic activities
against a variety of neurodegenerative diseases, including Alzheimer's disease (AD) and …

While neuronal mitochondria have been studied extensively in their role in health and
disease, the rules that govern calcium regulation in mitochondria remain somewhat vague …

A variety of factors has been associated with healthy brain aging, and epidemiological
studies suggest that physical activity and nutritional supplements such as caffeine may …