Historically, the ability of a ligand to bind to its receptor and the ability to subsequently
activate that receptor have been described as the properties of affinity and intrinsic efficacy …

Pharmacology is an integrative discipline that originated from activities, now nearly 7000
years old, to identify therapeutics from natural product sources. Research in the 19th …

A novel series of muscarinic receptor ligands of the hexamethonio-type was prepared which
contained, on one side, the phthalimidopropane or 1, 8-naphthalimido-2, 2-dimethylpropane …

Adenosine and adenine nucleotides exert potent extracellular actions on a wide range of
physiological systems, including the nervous, cardiovascular, gastrointestinal, urogenital …

In this study the similarities and differences between the M2 and M4 subtypes in their
recognition of agonists were explored. A CHO-K1 cell line transfected with the human m2 …

While much pharmacological effort has been expended in the measurement, quantification,
and comparison of agonist affinity for the classification of drugs and drug receptors …

The cardiac stimulant actions of nine β-adrenoceptor blocking agents were examined in
kitten papillary muscles and in isolated atria of kittens and guinea pigs to determine to what …

Abstract 1 A method is described for deriving null equations for functional antagonism and
synergism. These null equations relate together the concentrations of agonist required to …

Two subsets of tertiary amines (1a-6a) and methiodides (1b-6b) with a structural
resemblance to oxotremorine and oxotremorine-M were tested at rabbit vas deferens (M1) …

MOST pharmacological observations support the hypothesis that drugs produce their effects
by interacting in a specific way with some component of the living cell. This component …