[HTML][HTML] Unveiling the effect of low pH on the SARS-CoV-2 main protease by molecular dynamics simulations

HL Barazorda-Ccahuana, M Nedyalkova, F Mas… - Polymers, 2021 - mdpi.com
(1) Background: Main Protease (Mpro) is an attractive therapeutic target that acts in the
replication and transcription of the SARS-CoV-2 coronavirus. Mpro is rich in residues …

[HTML][HTML] In silico analysis of metabolites from Peruvian native plants as potential therapeutics against Alzheimer's disease

LD Goyzueta-Mamani, HL Barazorda-Ccahuana… - Molecules, 2022 - mdpi.com
Background: Despite research on the molecular bases of Alzheimer's disease (AD), effective
therapies against its progression are still needed. Recent studies have shown direct links …

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

V Srinivasan, H Brognaro, PR Prabhu, EE de Souza… - Biorxiv, 2021 - biorxiv.org
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, PLpro has the additional and vital function of removing ubiquitin …

Hydrogen-bond-assisted topochemical synthesis of a multivalent zwitterionic tetramer via concomitant cross-and homo [2+ 2] photocycloadditions. Theoretical antiviral …

A Escalona, FW Heinemann, A Briceño… - New Journal of …, 2023 - pubs.rsc.org
Compound [(3-H2PA)(HCh)]· 2H2O (1) represents a novel example of an ionic co-crystal
that undergoes regioselectively a triple photoreaction to form a rare multivalent …

Computer-aided Drug Discovery Approaches in the Identification of Natural Products against SARS-CoV-2: A Review

MM Junqueira Ribeiro - Current Computer-Aided Drug Design, 2024 - ingentaconnect.com
The COVID-19 pandemic is raising a worldwide search for compounds that could act against
the disease, mainly due to its mortality. With this objective, many researchers invested in the …

[PDF][PDF] F. Alvarez, KL; Aguilar-Pineda, JA; Vera-Lopez, KJ; Lino Cardenas, CL In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics …

LD Goyzueta-Mamani, HL Barazorda-Ccahuana… - Molecules, 2022 - academia.edu
Background: Despite research on the molecular bases of Alzheimer's disease (AD), effective
therapies against its progression are still needed. Recent studies have shown direct links …

[HTML][HTML] Peruvian contributions to scientific publications on experimental research against COVID-19: a systematic review

K Coronel-Monje, MA Candia-Puma… - …, 2023 - f1000research.com
Background One of the countries most adversely affected by the COVID-19 outbreak was
Peru. Worldwide scientific knowledge creation has significantly grown because of this …

In silico-based screening for natural product's structural analogs as new drugs candidate against leishmaniasis

HL Barazorda-Ccahuana, LD Goyzueta-Mamani… - bioRxiv, 2022 - biorxiv.org
Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new
cases each year. Despite the new approaches and advances to fight the disease, there are …

[HTML][HTML] Identification of compounds from natural Peruvian sources as potential inhibitors of SARS-CoV-2 Mpro mutations by virtual screening and computational …

HL Barazorda-Ccahuana… - …, 2024 - f1000research.com
Background The coronavirus disease (COVID-19) pandemic continues to be a public health
problem worldwide. Several therapeutic targets of the severe acute respiratory syndrome …

A Systematic Review of Peruvian Contributions to Scientific Publications on Experimental Research Against COVID-19

K Coronel-Monje, MA Candia-Puma, JJ Vilca-Alosilla… - medRxiv, 2023 - medrxiv.org
One of the countries most adversely affected by the COVID-19 outbreak was Peru.
Worldwide scientific knowledge creation has significantly grown because of this pandemic …