Characterization of key residues and membrane association domains in retinol dehydrogenase 10

Y Takahashi, G Moiseyev, K Farjo, J Ma - Biochemical Journal, 2009 - portlandpress.com
RDH10 (retinol dehydrogenase 10) was originally identified from the retinal pigment
epithelium and retinal Müller cells. It has retinoid oxidoreductase activity and is thought to …

Protein engineering of redox-active enzymes

G Saab-Rincon, B Valderrama - Antioxidants & redox signaling, 2009 - liebertpub.com
Redox-active enzymes perform many key biological reactions. The electron transfer process
is complex, not only because of its versatility, but also because of the intricate and delicate …

Arginine 276 controls the directional preference of AKR1C9 (rat liver 3α-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells

M Papari-Zareei, A Brandmaier, RJ Auchus - Endocrinology, 2006 - academic.oup.com
Rat liver AKR1C9 is the best-studied 3α-hydroxysteroid dehydrogenase (3αHSD) of the aldo-
keto reductase superfamily. The physiologic function of AKR1C9 is to catalyze the reduction …

Significance of individual amino acid residues for coenzyme and substrate specificity of 17β-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus

K Kristan, TL Rižner, J Stojan, JK Gerber… - Chemico-biological …, 2003 - Elsevier
17β-Hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus (17β-HSDcl) is a
NADPH dependent member of the short-chain dehydrogenase reductase (SDR) …

How estrogen‐specific proteins discriminate estrogens from androgens: A common steroid‐binding site architecture

V Nahoum, A Gangloff, R Shi, SX Lin - The FASEB journal, 2003 - Wiley Online Library
Steroid hormones play an essential role in a wide range of physiological and pathological
processes, such as growth, metabolism, aging, and hormone‐sensitive cancers. Estrogens …

Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase

H Cho, MA Oliveira, HH Tai - Archives of Biochemistry and Biophysics, 2003 - Elsevier
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a member of the
short chain dehydrogenase/reductase (SDR) family, is responsible for the biological …

Coenzyme specificity in fungal 17β-hydroxysteroid dehydrogenase

K Kristan, J Stojan, G Möller, J Adamski… - Molecular and cellular …, 2005 - Elsevier
The 17β-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus is an NADP
(H)-dependent member of the short-chain dehydrogenase/reductase superfamily (SDR) that …

Lipid-mediated unfolding of 3β-hydroxysteroid dehydrogenase 2 is essential for steroidogenic activity

M Rajapaksha, JL Thomas, M Streeter, M Prasad… - Biochemistry, 2011 - ACS Publications
For inner mitochondrial membrane (IMM) proteins that do not undergo N-terminal cleavage,
the activity may occur in the absence of a receptor present in the mitochondrial membrane …

The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing

L Zemanová, P Kirubakaran, IH Pato… - International journal of …, 2017 - Elsevier
Abstract Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-
chain dehydrogenase/reductase superfamily. The members of this superfamily often play an …

Elucidation of ligand binding and dimerization of NADPH:protochlorophyllide (Pchlide) oxidoreductase from pea (Pisum sativum L.) by structural analysis and …

H Sameer, G Victor, S Katalin… - … : Structure, Function, and …, 2021 - Wiley Online Library
Abstract NADPH: protochlorophyllide (Pchlide) oxidoreductase (POR) is a key enzyme of
chlorophyll biosynthesis in angiosperms. It is one of few known photoenzymes, which …