Search for new steroid hormone metabolizing enzymes: functional genomics of the short-chain dehydrogenase/reductase superfamily
BD Keller - 2006 - mediatum.ub.tum.de
Aim of the study was a functional genomic analysis of the Short-Chain Dehydrogenase/
Reductase family. For enzymatical characterization, expression pattern, activity towards …
Reductase family. For enzymatical characterization, expression pattern, activity towards …
Molecular characterization and homology modeling of a short-chain reductase/dehydrogenase from Gracilaria changii (Rhodophyta)
NAH Naseron, KA Lim, SL Teh, SS Teo… - Journal of applied …, 2014 - Springer
Short-chain dehydrogenases (SDRs) which catalyze the dehydrogenation/reduction
reaction have a wide range of substrate specificities. In this study, we report the molecular …
reaction have a wide range of substrate specificities. In this study, we report the molecular …
[PDF][PDF] Synthesis, Reactivity and Biological Activity of 17β-HSD1 Inhibitors Based on a Thieno [2, 3-d] pryrimidin-4 (3H)-one Core
A Lilienkampf - 2007 - core.ac.uk
Breast cancer is the most common cancer in women in Western countries. In the early
stages of development most breast cancers are hormone-dependent, and estrogens …
stages of development most breast cancers are hormone-dependent, and estrogens …
Chemical synthesis, characterisation and biological evaluation of furanic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1
S Farhane, Y Laplante, D Poirier - Medicinal Chemistry, 2011 - ingentaconnect.com
Local biosynthesis of estrogens, especially estradiol (E2), is thought to be important for the
maintenance and growth of estrogen-sensitive diseases. To control E2 formation, we have …
maintenance and growth of estrogen-sensitive diseases. To control E2 formation, we have …
Secretory expression, purification and functional characterization of 17β-hydroxysteroid dehydrogenase type 1 from mammalian HEK293T cells
J Chen, W Feng, Y Zhao - Protein Expression and Purification, 2017 - Elsevier
Abstract 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) mainly catalyzes the
reduction of estrone into estradiol. The enzymatic conversion is a critical step in estradiol …
reduction of estrone into estradiol. The enzymatic conversion is a critical step in estradiol …
[PDF][PDF] MoDÉLISATION MoLÉCULAIRE DE LA 17BÊTA
J BLANCHET - collectionscanada.gc.ca
Résumé La 17ß-hydroxystéroïde déshydrogénase humaine type 1 est une enzyme majeure
de la biosynthèse des oestrogènes qui est également impliquée dans le cancer du sein …
de la biosynthèse des oestrogènes qui est également impliquée dans le cancer du sein …
[PDF][PDF] Structural and Physiologic Determinants of Estrone/Estradiol Metabolism Catalyzed by Human 17beta-Hydroxysteroid Dehydrogenases Types 1 and 2
DP Sherbet - 2006 - utswmed-ir.tdl.org
The 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) types 1 and 2 interconvert the
weak and potent estrogens estrone and 17beta-estradiol. In intact cells, each enzyme …
weak and potent estrogens estrone and 17beta-estradiol. In intact cells, each enzyme …
[PDF][PDF] Structure-biological function study of 17B-hydroxysteroid dehydrogenase type 1 and reductive steroid enzymes: inhibitor design targeting estrogen-dependent …
A Tang - 2019 - dam-oclc.bac-lac.gc.ca
Human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the activation of
the most potent estrogen estradiol as well as the deactivation of the most active androgen …
the most potent estrogen estradiol as well as the deactivation of the most active androgen …
Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of highly potent inhibitors enabling a proof of principle study in rodents
ASA Ahmed - 2013 - publikationen.sulb.uni-saarland.de
Estradiol is the most potent estrogen in humans. It is known to be involved in development
and proliferation of estrogen dependent diseases such as breast cancer and endometriosis …
and proliferation of estrogen dependent diseases such as breast cancer and endometriosis …