Paracoccidioidomycosis (PCM), initially reported in 1908 in the city of São Paulo, Brazil, by
Adolpho Lutz, is primarily a systemic and neglected tropical mycosis that may affect …

Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

Hydrazide–hydrazone derivatives are present in many bioactive molecules and display a
wide variety of biological activities, such as antibacterial, antitubercular, antifungal …

Introduction The term invasive candidiasis (IC) refers to both bloodstream and deep-seated
invasive infections, such as peritonitis, caused by Candida species. Several guidelines on …

Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS
patients and other immunocompromised individuals are at risk for OIs, which if not treated …

Results Candiduria was detected in 0.11–0.75% of positive samples from outpatients, while
this number was significantly higher for inpatients, ranging between 3.49–10.63%(p< 0.001) …

Invasive fungal infections are becoming a major health concern in several groups of patients
leading to severe morbidity and mortality. Moreover, cutaneous fungal infections are a major …

Several new antifungals are currently in late-stage development, including those with novel
pharmacodynamics/mechanisms of action that represent new antifungal classes …

Invasive fungal infections remain a major cause of morbidity and mortality in
immunocompromised patients, and such infections are a substantial burden to healthcare …

Clinically available antifungals for the treatment of invasive fungal infections primarily target
either ergosterol in the fungal cell membrane or 1, 3-β-D-glucan in the fungal cell wall …