Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

Importance Three-dimensional cerebral organoids generated from patient-derived induced
pluripotent stem cells (iPSCs) may be used to interrogate cellular-molecular underpinnings …

We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …

The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the
function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar …

Bipolar disorder (BD) is a complex mental disorder with high mortality and disability rates
worldwide; however, research on its pathogenesis and diagnostic methods remains limited …

Lithium has been a drug for bipolar disorders (BD) for over 70 years; however, its usage has
been limited by its narrow therapeutic window (between 0.6 and 1.2 mM). Understanding the …

Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …

Background Reprogramming human induced pluripotent stem cells (iPSCs) from somatic
cells and generating three-dimensional brain organoids from these iPSCs provide access to …