Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
The blood-brain barrier (BBB) regulates molecular trafficking, protects against pathogens,
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …
and prevents efficient drug delivery to the brain. Models to date failed to reproduce the …
Advances in microfluidic blood–brain barrier (BBB) models
Therapeutic options for neurological disorders currently remain limited. The intrinsic
complexity of the brain architecture prevents potential therapeutics from reaching their …
complexity of the brain architecture prevents potential therapeutics from reaching their …
Recent progress in translational engineered in vitro models of the central nervous system
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …
models of the CNS. Current animal models lack many essential human characteristics (in …
The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering
P Abdollahiyan, F Oroojalian… - Journal of controlled …, 2021 - Elsevier
As a milestone in therapeutic fields, tissue engineering has offered an alternative strategy to
address unmet clinical needs for the repair and replacement of human damaged organs …
address unmet clinical needs for the repair and replacement of human damaged organs …
Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization
As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform
M Pinto, V Silva, S Barreiro, R Silva, F Remião… - Ageing Research …, 2022 - Elsevier
The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
The blood–brain barrier (BBB) represents a key challenge in developing brain-penetrating
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …
Stem cells for next level toxicity testing in the 21st century
E Fritsche, T Haarmann‐Stemmann, J Kapr, S Galanjuk… - Small, 2021 - Wiley Online Library
The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …