Angiogenic signaling pathways and anti-angiogenic therapy for cancer
ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …
Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-κB activation: a review of the molecular mechanisms
J Korbecki, D Simińska… - International journal of …, 2021 - mdpi.com
Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
are two types of hypoxia occurring in malignant tumors. They are both associated with the …
[HTML][HTML] Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
Y Xu, J Xiong, X Sun, H Gao - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer immunotherapy has significantly flourished and revolutionized the limited
conventional tumor therapies, on account of its good safety and long-term memory ability …
conventional tumor therapies, on account of its good safety and long-term memory ability …
Tumor angiogenesis and anti-angiogenic strategies for cancer treatment
Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …
ones and it is involved in both physiological and pathological processes of the body …
Non-small cell lung cancer targeted therapy: drugs and mechanisms of drug resistance
J Wu, Z Lin - International journal of molecular sciences, 2022 - mdpi.com
The advent of precision medicine has brought light to the treatment of non-small cell lung
cancer (NSCLC), expanding the options for patients with advanced NSCLC by targeting …
cancer (NSCLC), expanding the options for patients with advanced NSCLC by targeting …
[HTML][HTML] Targeting iron metabolism in cancer therapy
Iron is a critical component of many cellular functions including DNA replication and repair,
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …
The extracellular matrix in tumor progression and metastasis
JA Eble, S Niland - Clinical & experimental metastasis, 2019 - Springer
The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …
network of extracellular proteins, proteoglycans and glycoproteins, which form …
[HTML][HTML] Dual EGFR-VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC
X Le, M Nilsson, J Goldman, M Reck… - Journal of Thoracic …, 2021 - Elsevier
The vascular endothelial growth factor (VEGF) pathway has been recognized as a key
mediator of angiogenesis to support tumorigenesis. Multiple therapeutic agents targeting …
mediator of angiogenesis to support tumorigenesis. Multiple therapeutic agents targeting …
[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF
S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …
between health and disease. In spite of its central role in physiological homeostasis, it …
Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect
Bone defect repair is a challenging clinical problem in musculoskeletal system, especially in
orthopaedic disorders such as steroid associated osteonecrosis (SAON). Magnesium (Mg) …
orthopaedic disorders such as steroid associated osteonecrosis (SAON). Magnesium (Mg) …