β-Lactam antibiotics are one of the most important antibiotic classes but are plagued by
problems of resistance, and the development of new β-lactam antibiotics through side-chain …

Vancomycin has been used as the last resort in the clinical treatment of serious
Staphylococcus aureus infections. Vancomycin-intermediate S. aureus (VISA) was …

Among the 16 two-component systems in the opportunistic human pathogen
Staphylococcus aureus, only WalKR is essential. Like the orthologous systems in other …

Exposure of Staphylococcus aureus to cell wall inhibitors leads to the activation of the
VraTSR three-component sensory regulatory system. This system is composed of VraS, a …

The development of resistance to β-lactam antibiotics has made Staphylococcus aureus a
clinical burden on a global scale. MRSA (methicillin-resistant S. aureus) is commonly known …

Staphylococcus aureus has evolved a complex regulatory network that controls a multitude
of defense mechanisms against the deleterious effects of oxidative stress stimuli …

In Staphylococcus aureus, the transcription factor CodY modulates the expression of
hundreds of genes, including most virulence factors, in response to the availability of key …

Staphylococcus aureus produces several virulence factors that allow it to cause a variety of
infections. One of the major virulence factors is the capsule, which contributes to the survival …

The molecular mechanism underlying the development of vancomycin-intermediate
Staphylococcus aureus (VISA) remains unclear. The abuses of antibacterial compounds …

Staphylococcus aureus has a complex regulatory network for controlling the production of
capsule polysaccharide. In S. aureus, capsule production is controlled by several regulators …