Innovations in genomics and big data analytics for personalized medicine and health care: A review
Big data in health care is a fast-growing field and a new paradigm that is transforming case-
based studies to large-scale, data-driven research. As big data is dependent on the …
based studies to large-scale, data-driven research. As big data is dependent on the …
The role of pharmacogenomics in adverse drug reactions
R Cacabelos, N Cacabelos, JC Carril - Expert Review of Clinical …, 2019 - Taylor & Francis
ABSTRACT Introduction: Adverse drug reactions (ADRs) are a major health concern
worldwide. There are multiple causes of ADRs, some of which are preventable …
worldwide. There are multiple causes of ADRs, some of which are preventable …
Role of bioinformatics and pharmacogenomics in drug discovery and development process
P Katara - Network Modeling Analysis in Health Informatics and …, 2013 - Springer
Drug discovery and development is a complex, high risk, time consuming and potentially
highly rewarding process. Pharmaceutical companies literally burn millions of dollar per …
highly rewarding process. Pharmaceutical companies literally burn millions of dollar per …
[HTML][HTML] Improving the translation of animal ischemic stroke studies to humans
GC Jickling, FR Sharp - Metabolic brain disease, 2015 - Springer
Despite testing more than 1,026 therapeutic strategies in models of ischemic stroke and 114
therapies in human ischemic stroke, only one agent tissue plasminogen activator has …
therapies in human ischemic stroke, only one agent tissue plasminogen activator has …
Pharmacogenomics in early-phase clinical development
T Burt, S Dhillon - Pharmacogenomics, 2013 - Taylor & Francis
Pharmacogenomics (PGx) offers the promise of utilizing genetic fingerprints to predict
individual responses to drugs in terms of safety, efficacy and pharmacokinetics. Early-phase …
individual responses to drugs in terms of safety, efficacy and pharmacokinetics. Early-phase …
Quality by design (QbD) approach of pharmacogenomics in drug designing and formulation development for optimization of drug delivery systems
Conventional approaches of drug discovery are very complex, costly and time consuming.
But after the completion of human genome project, applications of pharmacogenomics in …
But after the completion of human genome project, applications of pharmacogenomics in …
Pharmacogenetic testing: current evidence of clinical utility
J Moaddeb, SB Haga - Therapeutic advances in drug safety, 2013 - journals.sagepub.com
Over the last decade, the number of clinical pharmacogenetic tests has steadily increased
as understanding of the role of genes in drug response has grown. However, uptake of …
as understanding of the role of genes in drug response has grown. However, uptake of …
Pharmacogenomic knowledge representation, reasoning and genome-based clinical decision support based on OWL 2 DL ontologies
Background Every year, hundreds of thousands of patients experience treatment failure or
adverse drug reactions (ADRs), many of which could be prevented by pharmacogenomic …
adverse drug reactions (ADRs), many of which could be prevented by pharmacogenomic …
Genetic polymorphisms of cytochrome P450 enzymes and transport proteins in a Russian population and three ethnic groups of Dagestan
KB Mirzaev, DA Sychev, KA Ryzhikova… - Genetic Testing and …, 2017 - liebertpub.com
Aim: The objective of this study was to investigate the prevalence of polymorphic markers of
the CYP2C19, CYP2C9, CYP2D6, SLCO1B1, and ABCB1 genes among the three ethnic …
the CYP2C19, CYP2C9, CYP2D6, SLCO1B1, and ABCB1 genes among the three ethnic …
Plant antimicrobial peptides as potential tool for topic treatment of hidradenitis suppurativa
Among chronic skin autoinflammatory diseases, Hidradenitis Suppurativa (HS) stands out
for its chronicity, highly variable condition, and profound impact on the patients' quality of life …
for its chronicity, highly variable condition, and profound impact on the patients' quality of life …