Microtubules are important cellular targets for anticancer therapy because of their key role in
mitosis. Microtubule inhibitors (MTI) such as taxanes, vinca alkaloids, and epothilones …

Background: The first tubulin targeting agents were approved as cancer chemotherapeutics
over 40 years ago and tubulin as an antitumor target continues to attract significant drug …

Ionic liquid based, ultrasound-assisted extraction (ILUAE) was successfully applied to the
extraction of 3 alkaloids, vindoline, catharanthine and vinblastine, from Catharanthus …

Qualitätsindikatoren wurden durch Sens et al. wie folgt definiert:„Ein Indikator ist ein
quantitatives Maß, welches zum Monitoring und zur Bewertung der Qualität wichtiger …

After failure of first-line chemotherapy for advanced non-small cell lung cancer, many
patients remain candidates to receive further antitumor treatment. To guide clinical …

Background This phase III randomized trial compared pemetrexed 500 mg/m 2 (P500) with
pemetrexed 900 mg/m 2 (P900) to determine whether higher dosing benefits non-small-cell …

Two molecularly imprinted polymers (MIP) for catharanthine and vindoline have been
synthesized in order to specifically extract these natural indole alkaloids from Catharanthus …

疗. 目前推荐的二线治疗药物主要是多西紫杉醇, 培美曲赛和EGFR-TKIs. 多西紫杉醇最先确立其
二线治疗的地位. 培美曲赛通过一项与多西紫杉醇进行随机对照的III 期研究批准用于晚期 …

Background To assess the efficacy of second-line treatments in non-small cell lung cancer.
Methods A systematic review of literature with metaanalysis of randomized clinical trials was …

Background. Indirect evidence is particularly valuable in health care decision making when
direct trial evidence comparing relevant treatments is absent or limited. Current approaches …