Peptides carry important functions in normal physiological and pathophysiological
processes and can serve as clinically useful biomarkers. Given the ability to diffuse …

OBJECTIVE: Osteoarthritis (OA) is the most common rheumatic pathology. It is related to
aging and is characterized primarily by cartilage degradation. Despite its high prevalence …

Background Renal involvement was thought to occur more than 10 years after onset of
diabetes, but recent studies provide evidence that it starts even in the pre-diabetes stage …

Renal dysfunction, a major complication of type 2 diabetes, can be predicted from estimated
glomerular filtration rate (eGFR) and protein markers such as albumin concentration. Urinary …

Background The blood proteome is thought to represent a rich source of biomarkers for early
stage disease detection. Nevertheless, three major challenges have hindered biomarker …

OBJECTIVE Chronic renal insufficiency and/or proteinuria in type 2 diabetes may stem from
chronic renal diseases (CKD) other than classic diabetic nephropathy in more than one-third …

Diabetes is often associated with chronic kidney disease (CKD) and is the primary cause of
kidney failure in half of patients who receive dialysis therapy. Given the increasing …

Preeclampsia continues to plague some of the most vulnerable women and fetuses. It is
surprisingly prevalent in developing and developed nations. According to the World Health …

Research on extracellular vesicles (EVs), both in general laboratory methods and in novel
therapeutic approaches, is limited by the difficulty of obtaining large quantities of EVs. This is …

Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been
evaluated. The aim of this study was to evaluate the association of plasma and/or urine α …