The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …

The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

The extracellular matrix (ECM) is composed of highly variable and dynamic components that
regulate cell behavior. The protein composition and physical properties of the ECM govern …

The mechanical microenvironment is known to influence single-cell migration; however, the
extent to which mechanical cues affect collective migration of adherent cells is not well …

The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …

The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …

The extracellular matrix is a structure composed of many molecules, including fibrillar (types
I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens …

Abstract Enhancer of Zeste Homolog 2 (EZH2), a key epigenetic regulator, is involved in
breast cancer progression and metastasis. LOXL4 is increasingly recognized as an …