Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

Pancreatic β cells are functionally programmed to release insulin in response to changes in
plasma glucose concentration. Insulin secretion is precisely regulated so that, under normal …

Hyperinsulinemic hypoglycemia is the most common cause of severe, persistent neonatal
hypoglycemia. The treatment of hyperinsulinemic hypoglycemia that is unresponsive to …

Introduction: Neuroglycopenia is recognized to be associated with abnormal
neurodevelopmental outcomes in 26–44% of children with persistent congenital …

Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin
release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe …

Insulin secretion from pancreatic β-cells is tightly regulated to keep fasting blood glucose
concentrations within the normal range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia …

Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis
and treatment, it was considered necessary to formulate evidence-based clinical practice …

Background/aims Congenital hyperinsulinism (CHI) is a heterogeneous disease most
frequently caused by KATP-channel (ABCC8 and KCNJ11) mutations, with neonatal or later …

Epigenetic researchers often evaluate DNA methylation as a potential mediator of the effect
of social/environmental exposures on a health outcome. Modern statistical methods for …