Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases
and blocks cell death, is highly expressed in most cancers and is associated with a poor …

Neem (Azadirachta indica), a member of the Meliaceae family, is a fast growing tropical
evergreen tree with a highly branched and stout, solid stem. Because of its tremendous …

Background Assays of the abundance of immune cell populations in the tumor
microenvironment promise to inform immune oncology research and the choice of …

Besides gene-editing, the CRISPR/Cas12a system has also been widely used in in vitro
biosensing, but its applications in live-cell biosensing are rare. One reason is lacking …

Background: Melanoma is highly immunogenic and therefore suitable for immunotherapy,
but the efficacy is limited by response rate. In several types of tumor, tumor mutation burden …

Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …

Efficacy of regular chemotherapy is significantly hampered by multidrug resistance (MDR)
and severe systemic toxicity. The reduced toxicity has been evidenced after administration of …

Porphyromonas gingivalis can inhibit chemically induced apoptosis in primary cultures of
gingival epithelial cells through blocking activation of the effector caspase‐3. The anti …

Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of
locally advanced disease generally requires various combinations of radiotherapy, surgery …

Survivin belongs to the family of apoptosis inhibitors (IAPs), which antagonizes the induction
of cell death. Dysregulated expression of IAPs is frequently observed in cancers, and the …