Nanoparticles as drug delivery carriers have benefited diseases, including cancer, since the
1990s, and more recently, their promise to quickly and efficiently be mobilized to fight …

Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …

Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven
valuable for studies of kidney development, disease, and therapeutic screening. However …

Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following
injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and …

A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Recreating human tissues and organs in the petri dish to establish models as tools in
biomedical sciences has gained momentum. These models can provide insight into …

Organoid technology is rapidly gaining ground for studies on organ (patho) physiology.
Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The …

Polycystic kidney diseases (PKDs) are genetic disorders characterized by the formation and
expansion of numerous fluid-filled renal cysts, damaging normal parenchyma and often …

Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal
tubule that increase in number after acute kidney injury. We aimed to characterize the …

The rising prevalence of kidney diseases urges the need for novel therapies. Kidney
organoids and tubuloids are advanced in vitro models and have recently been described as …