Solriamfetol enhances wakefulness and improves cognition and anxiety in a murine model of OSA

M Badran, C Puech, MB Barrow, AR Runion, D Gozal - Sleep Medicine, 2023 - Elsevier
Background Obstructive sleep apnea (OSA) is a chronic condition characterized by
intermittent hypoxia (IH). Excessive daytime sleepiness (EDS) is a common consequence of …

Cognitive Impairments, Neuroinflammation and Blood–Brain Barrier Permeability in Mice Exposed to Chronic Sleep Fragmentation during the Daylight Period

C Puech, M Badran, AR Runion, MB Barrow… - International Journal of …, 2023 - mdpi.com
Obstructive sleep apnea (OSA) is a chronic condition characterized by intermittent hypoxia
(IH) and sleep fragmentation (SF). In murine models, chronic SF can impair endothelial …

Recovery Mimicking “Ideal” CPAP Adherence Does Not Improve Wakefulness or Cognition in Chronic Murine Models of OSA: Effect of Wake-Promoting Agents

M Badran, C Puech, MB Barrow, AR Runion… - Archivos de …, 2023 - Elsevier
Introduction Obstructive sleep apnea (OSA) is a chronic condition characterized by
intermittent hypoxia (IH) and sleep fragmentation (SF). OSA can induce excessive daytime …

药物治疗阻塞性睡眠呼吸暂停的研究进展

武兴东, 岳红梅, 朱浩斌, 刘苗苗… - 中国临床药理学与 …, 2024 - manu41.magtech.com.cn
阻塞性睡眠呼吸暂停(OSA) 是一种常见的睡眠呼吸障碍性疾病. 作为一种重要的全球公共卫生
问题, 未经治疗的OSA 可导致多种不良的健康后果, 包括各种心脑血管疾病, 代谢紊乱以及焦虑 …

Research progress of pharmacologic therapy in obstructive sleep apnea

X WU, H YUE, H ZHU, M LIU… - Chinese Journal of …, 2024 - manu41.magtech.com.cn
Obstructive sleep apnea (OSA) is a common sleep disordered breathing disorder. As a
major global public health problem, untreated OSA can lead to a variety of adverse health …