Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)

D Šamec, E Karalija, S Dahija, STS Hassan - Plants, 2022 - mdpi.com
Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent
resistance to various environmental conditions. It is used as an ornamental plant and is …

[2+ 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses

P Yang, Q Jia, S Song, X Huang - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to the end of 2021 [2+ 2]-Type cyclobutane natural products are
biosynthetically derived from intermolecular [2+ 2] cycloaddition or intramolecular [2+ 2] …

The CBS-H2S axis promotes liver metastasis of colon cancer by upregulating VEGF through AP-1 activation

S Guo, J Li, Z Huang, T Yue, J Zhu, X Wang… - British Journal of …, 2022 - nature.com
Background The main therapy for colon cancer with liver metastasis is chemotherapy based
on 5-fluorouracil combined with targeted drugs. However, acquired drug resistance and …

Modern techniques for flavonoid extraction—to optimize or not to optimize?

A Jurinjak Tušek, D Šamec, A Šalić - Applied Sciences, 2022 - mdpi.com
Flavonoids, specialized metabolites found in plants, have a number of beneficial properties
and are important for maintaining good health. Efficient extraction methods are required to …

Neuroprotective potential of biflavone ginkgetin: a review

İİ Tatlı Çankaya, HP Devkota, G Zengin, D Šamec - Life, 2023 - mdpi.com
Neurological disorders are becoming more common, and there is an intense search for
molecules that can help treat them. Several natural components, especially those from the …

Advances in the Anti-Tumor Activity of Biflavonoids in Selaginella

M Ren, S Li, Q Gao, L Qiao, Q Cao, Z Yang… - International Journal of …, 2023 - mdpi.com
Despite the many strategies employed to slow the spread of cancer, the development of new
anti-tumor drugs and the minimization of side effects have been major research hotspots in …

Spiro-Flavonoids in Nature: A Critical Review of Structural Diversity and Bioactivity

Ł Pecio, S Pecio, T Mroczek, W Oleszek - Molecules, 2023 - mdpi.com
Based on the literature data from 1973 to 2022, this work summarizes reports on spiro-
flavonoids with a spiro-carbon at the center of their structure and how this affects their …

Tissue-Specific Profiling of Biflavonoids in Ginkgo (Ginkgo biloba L.)

M Kovač Tomas, I Jurčević, D Šamec - Plants, 2022 - mdpi.com
Biflavonoids are flavonoid dimers that are much less studied than monomeric flavonoids.
Their precise distribution among plants and their role in plants is still unknown. Here, we …

A Comparative Analysis of Radical Scavenging, Antifungal and Enzyme Inhibition Activity of 3′-8 ″-Biflavones and Their Monomeric Subunits

I Jurčević Šangut, B Šarkanj, E Karalija, D Šamec - Antioxidants, 2023 - mdpi.com
Biflavonoids are dimeric forms of flavonoids that have recently gained importance as an
effective new scaffold for drug discovery. In particular, 3′-8 ″-biflavones exhibit antiviral …

Preparation of paclitaxel-encapsulated bio-functionalized selenium nanoparticles and evaluation of their efficacy against cervical cancer

S Menon, S Jayakodi, KK Yadav, P Somu, M Isaq… - Molecules, 2022 - mdpi.com
The potentiality of nanomedicine in the cancer treatment being widely recognized in the
recent years. In the present investigation, the synergistic effects of chitosan-modified …