[HTML][HTML] Emerging new therapeutic antibody derivatives for cancer treatment

S Jin, Y Sun, X Liang, X Gu, J Ning, Y Xu… - … and Targeted Therapy, 2022 - nature.com
Monoclonal antibodies constitute a promising class of targeted anticancer agents that
enhance natural immune system functions to suppress cancer cell activity and eliminate …

The making of bispecific antibodies

U Brinkmann, RE Kontermann - MAbs, 2017 - Taylor & Francis
During the past two decades we have seen a phenomenal evolution of bispecific antibodies
for therapeutic applications. The 'zoo'of bispecific antibodies is populated by many different …

Nanoparticle-based immunochemical biosensors and assays: recent advances and challenges

Z Farka, T Jurik, D Kovar, L Trnkova… - Chemical reviews, 2017 - ACS Publications
We review the progress achieved during the recent five years in immunochemical
biosensors (immunosensors) combined with nanoparticles for enhanced sensitivity. The …

Ligand-targeted drug delivery

M Srinivasarao, PS Low - Chemical reviews, 2017 - ACS Publications
Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

The global landscape of approved antibody therapies

X Lyu, Q Zhao, J Hui, T Wang, M Lin… - Antibody …, 2022 - academic.oup.com
Antibody therapies have become an important class of therapeutics in recent years as they
have exhibited outstanding efficacy and safety in the treatment of several major diseases …

The role of myeloid cells in cancer therapies

C Engblom, C Pfirschke, MJ Pittet - Nature Reviews Cancer, 2016 - nature.com
Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Biosensors for whole-cell bacterial detection

A Ahmed, JV Rushworth, NA Hirst… - Clinical microbiology …, 2014 - Am Soc Microbiol
Bacterial pathogens are important targets for detection and identification in medicine, food
safety, public health, and security. Bacterial infection is a common cause of morbidity and …

[HTML][HTML] The history of monoclonal antibody development–progress, remaining challenges and future innovations

JKH Liu - Annals of medicine and surgery, 2014 - Elsevier
As medicine progresses into a new era of personalised therapy, the use of monoclonal
antibodies to treat a wide range of diseases lies at the heart of this new forefront. Since the …

[HTML][HTML] Design and production of bispecific antibodies

Q Wang, Y Chen, J Park, X Liu, Y Hu, T Wang… - Antibodies, 2019 - mdpi.com
With the current biotherapeutic market dominated by antibody molecules, bispecific
antibodies represent a key component of the next-generation of antibody therapy. Bispecific …